Association between early and current gastro-intestinal symptoms and co-morbidities in children and adolescents with Angelman syndrome

About this research

Using information contributed by families to the Global Angelman Syndrome Registry, this study explored gastrointestinal (GI) symptoms in 173 children and adolescents with Angelman syndrome and their relationship with feeding history, sleep, toileting, communication and behaviour.

Gastrointestinal issues were very common. Constipation was reported in 84% of participants and gastroesophageal reflux in 64%. A higher frequency of GI symptoms was associated with several feeding and gastrointestinal difficulties during infancy, including vomiting, arching, difficulty gaining weight and reflux.

The findings highlight the significant burden of gastrointestinal problems in children and adolescents with Angelman syndrome and the importance of better understanding how these symptoms develop across the lifespan. The researchers also identified a need for further research into gastrointestinal issues in adults with Angelman syndrome.

Read the full publication

The full paper is available through the Journal of Intellectual Disability Research.